Medicinal Ingredients

Ingrédients

 

Capsaicine / Cayenne Capsicum annuum (0,75%)

Capsaicin works as an analgesic by decreasing a natural substance in your body (substance P) that helps decreasing the pain signals to the brain.

Arnica Oil (5%)

Analgesic, anti-inflammatory, healing, and circulatory properties.
Arnica’s primary function is anti-inflammatory. Indeed, sesquiterpene lactones are capable of inhibiting the oxidative phosphorylation of polynuclear cells as well as their migration. These molecules also prevent the rupture of the lysosomal membranes, thereby preserving the cell integrity. Finally, they have an anti-ecchymotic action associated with the inhibition of platelet aggregation. Finally, Arnica could also have analgesic properties.

Menthol (10%)

Pain-relieving and anti-inflammatory properties. Just like the application of ice on skin (or cryotherapy), menthol activates the skin thermoreceptors, which creates freshness sensation and deep analgesia. The thermoreceptors involved are the TRPM8 receptors sensitive to cold temperatures. Those are involved in the processess of inflammation, pain and itching (pruritus).

Dichlorhydrate d’histamine (0,025%)

Histamine dihydrochloride, helps alleviate pain. Once absorbed into the skin, it acts as a vasodilator, temporarily increasing the size of your blood vessels for greater circulation. This action safely and effectively reduces pain in the joint or muscle. This approved active ingredient is derived from histamine, an organic compound produced by your body.

 

Bibliography

Arnica

  • Arnica montana L. – a plant of healing: review. J Pharm Pharmacol. 2017 Aug;69(8):925-945. doi: 10.1111/jphp.12724. Epub 2017 Apr 11.
    Barnes Joan, Anderson A. Linda, Phillipson David J. Herbal Medicines, Pharmaceutical Press, Grande-Bretagne, 2002, 2e édition.
  • Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica Montana. Christian Lass L et al,
    Experimental Dermatology, 17:849–857. 2008.
  • The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits. The Transcription Factor NF-kB by Directly Targeting p65. Guido
    Lyß et al, The journal of Biological chemistry, 273(50):33508–33516. 1998.
  • Helenalin and 11α,13-dihydrohelenalin, two constituents from Arnica Montana L., inhibit human platelet function via thiol-dependent
    pathways. Schroder H et al. Thromb Res, 57: 839-845. 1990
  • European Scientific Cooperative on Phytotherapy (Ed). Arnicae flos, ESCOP Monographs on the Medicinal Uses of Plants Drugs, Centre for Complementary Health Studies, Université d’Exeter, Grande-Bretagne, 1997.
  • Natural Standard (Ed). Herbs & Supplements – Arnica, Nature Medicine Quality Standard.